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Treatment of indigestion occurring after food or alcohol ingestion. Treatment of diarrhea and controlling associated complaints eg, cramping, heartburn, nausea and stomach upset when administered following the occurrence of diarrhea, a significant reduction in the number of unformed stools. Treatment and prevention of traveler's diarrhea. Treatment of acute or chronic diarrhea of childhood. Bismuth subsalicylate alone has been effective in the treatment of gastritis and peptic ulcer associated with Helicobacter pylori infection. Bismuth subsalicylate in combination with proton pump inhibitor (PPI) or antimicrobial use is effective in the treatment of Helicobacter pylori-associated active duodenal ulcer disease.